Elsevier

Theriogenology

Volume 48, Issue 5, 1 October 1997, Pages 883-892
Theriogenology

Endocrine basis for testicular function in the stallion

https://doi.org/10.1016/S0093-691X(97)00309-9Get rights and content

Abstract

The specific nature and relative contribution of the various factors involved in the endocrine/paracrine/autocrine control of reproductive function in normal stallions are not well defined nor have they been elucidated in the idiopathic subfertile/infertile stallion. Over the last 9 years, work in our laboratory has been focused in characterizing the hypothalamic-pituitary-testicular axis in fertile, subfertile (idiopathic oligospermia) and infertile (idiopathic azoospermia) stallions. We have identified endocrine factors and mechanisms important for normal reproductive function, and demonstrated specific hormonal changes in pituitary and testicular function between fertile, subfertile and infertile stallions. Recent evidence suggests that the primary defect is at the level of the testes. The nature of the dysfunction does not appear to involve changes in LH receptor binding kinetics but may be related to post-receptor mechanisms.

References (47)

  • A Bartke

    Hyperprolactinemia and male reproduction

  • J.M. Belanger et al.

    Gonadotropin levels and pituitary responsiveness in fertile (F), subfertile (SF) and infertile (IF) stallions prior to and after castration

  • J Bell et al.

    Heterogeneity of gonadotropin response to LHRH in hypogonadotropic hypogonadism

    J Clin Endocrinol Metab

    (1973)
  • T.L. Blanchard et al.

    Testicular degeneration

  • B.J. Blue et al.

    Effect of pulsatile or continuous administration of GnRH on reproductive function of stallions

    J Reprod Fertil Suppl

    (1991)
  • M.S. Boyle et al.

    The effects of continuous treatment of stallions with high levels of a potent GnRH analogue

    J Reprod Fertil Suppl

    (1991)
  • R.H. Douglas et al.

    Endocrine abnormalities and hormonal therapy

    Vet Clin North Am

    (1992)
  • K.F. Dowsett

    Seminal abnormalities

  • K.M. Eisenhauer et al.

    Effects of lipoproteins, eLH, eFSH and ePRL on equine testicular steroidogenesis in vitro

    J Androl

    (1995)
  • A.J. Hsueh et al.

    Heterodimers and monodimers of inhibin subunits have different paracrine actions in the modulation of luteinizing hormone-stimulated androgen biosynthesis

  • J Inoue et al.

    Serum levels of testosterone and oestrogens in normal and infertile stallions

    Int J Androl

    (1993)
  • T Lin et al.

    Regulation of Leydig cell function in primary culture by inhibin and activin

    Endocrinology

    (1989)
  • J.C. Marshall et al.

    Isolated pituitary gonadotrophin deficiency: Gonadotrophin secretion after synthetic luteinizing hormone and follicle stimulating hormone-releasing hormone

    Brit Med J

    (1972)
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